Safety and tolerability of DepoFoam ® encapsulated bupivacaine for epidural nerve block in rats and dogs
نویسندگان
چکیده
منابع مشابه
Effect of Epidural Anesthesia with Lidocaine and Bupivacaine on Gastrointestinal Transit Time in Healthy Dogs
Objective- To evaluate the effect of epidural anesthesia with lidocaine and bupivacaine on transit time of barium sulfate contrast medium through gastrointestinal (GI) tracts in healthy dogs. Design- Prospective, randomized experimental study. Animals-Five healthy mixed breed male dogs with 19.2±7.8 months age and 19.9±3.3 kg weight Procedure- The animals received one of the treatments of sa...
متن کاملEpidural Analgesia with Bupivacaine, Ketamine, and the Combination of Bupivacaine and Ketamine in Sheep
Objective- To evaluate the effects of bupivacaine (B), ketamine (K), and a combination of bupivacaine and ketamine (BK) after lumbosacral epidural analgesia in sheep. Design- Experimental study. Animals- Nine healthy male and non-pregnant female Iranian Chall sheep with mean body weight of 38.9 ± 15.1 kg. Procedures- Animals were selected randomly and three treatments administered. The ...
متن کاملSafety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by Repeated Subcutaneous Injection in Rabbits and Dogs: Species Comparison
EXPAREL (bupivacaine extended-release liposome injection), DepoFoam bupivacaine, is in development for prolonged postsurgical analgesia. Repeat-dose toxicity studies were conducted in rabbits and dogs to compare the potential local and systemic toxicities of EXPAREL and bupivacaine HCl (Bsol), and the reversibility of any effects. Dogs tolerated much larger doses than rabbits. EXPAREL-related m...
متن کاملThe Safety of EXPAREL ® (Bupivacaine Liposome Injectable Suspension) Administered by Peripheral Nerve Block in Rabbits and Dogs
A sustained-release DepoFoam injection formulation of bupivacaine (EXPAREL, 15 mg/mL) is currently being investigated for postsurgical analgesia via peripheral nerve block (PNB). Single-dose toxicology studies of EXPAREL (9, 18, and 30 mg/kg), bupivacaine solution (Bsol, 9 mg/kg), and saline injected around the brachial plexus nerve bundle were performed in rabbits and dogs. The endpoints inclu...
متن کاملsimulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water
abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.760.7